Author

M. R. Patel

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Evolutionary Biology· 2

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Organism:C. elegans· 5 Approach:experimental assay· 5 Research Focus:chromatin & epigenetic regulation· 3 Research Focus:development & morphogenesis· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Assay:DNA methylation· 2 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

B. L. Gitschlag· 2 shared J. P. Held· 2 shared N. Tsyba· 2 shared A. T. Tate· 1 shared A. Z. Schwartz· 1 shared B. R. Saunders· 1 shared C. V. Pereira· 1 shared C. V. Pereria· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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2 shared papersEvolutionary Biology

B. L. Gitschlag

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5 papers

Recent·Most cited

Independent regulation of mtDNA quantity and quality resets the mitochondrial genome in C. elegans primordial germ cells

A. Z. Schwartz, N. Tsyba, Y. Abdu, M. R. Patel, J. Nance

The paper shows that C. elegans primordial germ cells use separate mechanisms to control mtDNA quantity and quality, resetting the mitochondrial genome.

bioRxiv · May 6, 2022Cell Biology

Multiple distinct evolutionary mechanisms govern the dynamics of selfish mitochondrial genomes

B. L. Gitschlag, C. V. Pereira, J. P. Held, D. M. McCandlish, M. R. Patel

The paper investigates evolutionary mechanisms of selfish mitochondrial genomes in C. elegans, revealing diverse strategies for persistence and phenotypic consequences.

bioRxiv · Apr 8, 2022 · PreprintEvolutionary Biology

Tissue-specific heteroplasmy dynamics is accompanied by a sharp drop in mtDNA copy number during development

N. Tsyba, M. R. Patel

The paper measures heteroplasmy levels and mtDNA copy number in C. elegans neurons and muscles during development, finding tissue-specific differences and significant mtDNA loss.

bioRxiv · Jul 30, 2021 · PreprintCell Biology

A tRNA processing enzyme is a central regulator of the mitochondrial unfolded protein response

J. P. Held, B. R. Saunders, C. V. Pereria, M. R. Patel

This study identifies HOE-1, a tRNA processing enzyme, as a central regulator of UPRmt in C. elegans, revealing its mechanism involving tRNAs and transcription factors.

bioRxiv · Jun 22, 2021Cell Biology

Selfish mitochondria exploit nutrient status across different levels of selection

B. L. Gitschlag, A. T. Tate, M. R. Patel

This study shows that selfish mitochondrial DNA variants exploit nutrient status to compete within hosts, with their advantage dependent on the FoxO transcription factor DAF-16 during food scarcity.

bioRxiv · Jan 30, 2020 · PreprintEvolutionary Biology