Targeting Unique Ligand Binding Domain Structural Features Downregulates DKK1 in Y537S ESR1 Mutant Breast Cancer Cells
K. S. Young, G. R. Hancock, E. C. Fink, A. Zigrossi, B. Flowers, D. A. Cooper, V. T. Ngyuen, M. Martinez, K. S. Mon, M. C. Bosland, D. Zak, A. P. Runde, M. N. Sharifi, I. Kastrati, D. Minh, , S. W. Fanning
This study investigates how a novel SERM, T6I-29, downregulates DKK1 in Y537S ESR1 mutant breast cancer cells and identifies DKK1 as a potential therapeutic target.
bioRxiv · May 28, 2024Cancer Biology