M. Martinez

Evolutionary plasticity and functional repurposing of the essential metabolic enzyme MoeA

The paper investigates how the MoeA enzyme evolved multifunctionality through evolutionary and structural analyses, showing its repurposing in both bacteria and eukaryotes for diverse roles.

Targeting Unique Ligand Binding Domain Structural Features Downregulates DKK1 in Y537S ESR1 Mutant Breast Cancer Cells

This study investigates how a novel SERM, T6I-29, downregulates DKK1 in Y537S ESR1 mutant breast cancer cells and identifies DKK1 as a potential therapeutic target.

Eukaryotic-like gephyrin and cognate membrane receptor coordinate corynebacterial cell division and polar elongation.

The paper identifies two new divisome members in Corynebacteriales and shows their role in coordinating cell division and polar elongation with the divisome and elongasome.

Evaluating the solubility of compounds intended for intramammary infusion based upon tests conducted across a range of milk products using cephapirin sodium and benzathine as model drugs

This paper evaluates drug solubility in milk products using cephapirin sodium and benzathine as model drugs, finding that whole milk or reconstituted milk can substitute for raw bovine milk for solubility assessments at 38°C.

Bacterial outer-membrane polysaccharide export (OPX) proteins occupy three structural classes with selective β-barrel porin requirements for polymer secretion

The paper identifies three structural classes of bacterial OPX proteins and shows that some use β-barrel porins for polysaccharide secretion when they cannot span the outer membrane.

In situ structure and priming mechanism of the rhoptry secretion system in Plasmodium revealed by cryo-electron tomography

This study uses cryo-electron tomography to reveal the structure and priming mechanism of the rhoptry secretion system in Plasmodium falciparum merozoites, identifying distinct organizational states and conformational changes in the RSA.

Gut microbiota and age shape susceptibility to clostridial enteritis in lorikeets under human care

The paper identifies gut microbiota and age factors associated with susceptibility to clostridial enteritis in lorikeets using 16S rRNA sequencing and machine learning models.

Functionalized Biomimetic Hydrogels Enhance Salivary Stem/Progenitor Cell Organization

This study functionalizes hydrogels to enhance salivary stem/progenitor cell organization and morphogenesis by optimizing crosslink density, integrin-binding sites, and porosity.

The low and high postpubertal ethanol use: long-term effects on drinkers reproductive parameters and ethanol-naive offspring development

This study examines the long-term effects of low and high postpubertal ethanol consumption on reproductive parameters and offspring development in rats, finding dose-related impairments.

Stimulation of the human mitochondrial transporter ABCB10 by zinc-mesoporphrin

This study identifies Zinc-mesoporphyrin as the first compound to directly modulate ABCB10 activity by increasing its ATPase activity in purified human ABCB10.

Cryo-EM structure of enteric adenovirus HAdV-F41 highlights structural divergence among human adenoviruses

The paper determines the cryo-EM structure of HAdV-F41, an enteric adenovirus, and compares it to other adenoviruses, revealing structural differences that enhance capsid stability for gut survival.

Central role and structure of the membrane pseudokinase YukC in the antibacterial Bacillus subtilis Type VIIb Secretion System.

This study investigates the Bacillus subtilis Type VIIb Secretion System (T7SSb), identifying YukC as a central pseudokinase subunit involved in secretion complex assembly and toxin recruitment.

Essential dynamic interdependence of FtsZ and SepF for Z-ring and septum formation in Corynebacterium glutamicum

This study investigates the essential interaction between FtsZ and SepF in C. glutamicum, revealing their dynamic roles in Z-ring and septum formation through structural and functional analyses.

Functional systemic CD4 immunity is a differential factor for clinical responses to PD-L1/PD-1 blockade therapy in lung cancer

This study identifies functional systemic CD4 immunity as a key predictor of response to PD-L1/PD-1 blockade therapy in lung cancer patients.

Automatic local resolution-based sharpening of cryo-EM maps.

This paper introduces a new automatic method for sharpening cryo-EM maps based on local resolution, improving map quality and interpretability.

Global landscape of mouse and human cytokine transcriptional regulation

The paper compiles a database of TF-cytokine gene interactions in human and mouse, identifies general principles of cytokine regulation, and highlights their relevance to immune phenotypes and diseases.