SOX9 binds TCFs to mediate Wnt/β catenin target gene activation
A.-B. Ramakrishnan, P. E. Burby, K. Adiga, K. M. Cadigan
The paper shows SOX9 promotes Wnt-driven CRC cell proliferation by activating enhancers that co-occupy TCFs and require SOX9 and TCF binding sites for transcriptional activation.
bioRxiv · Apr 6, 2022 · PreprintCancer Biology