Author

A.-H. Nguyen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1 Research Focus:protein folding & dynamics· 1 Assay:structural biology· 1

Frequent Co-Authors

A. Brown· 1 shared A. Schaefer· 1 shared A.-Q. Nguyen· 1 shared B. Yount· 1 shared C. Moy· 1 shared D. Babusis· 1 shared D. R. Martinez· 1 shared D. W. Taylor· 1 shared

Activity by Year

2023-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperMicrobiology

A. Brown

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Efficacy of the oral nucleoside prodrug GS-5245 (Obeldesivir) against SARS-CoV-2 and coronaviruses with pandemic potential

D. R. Martinez, F. Moreira, M. R. Zweigart, K. L. Gully, G. De la Cruz, A. Brown, L. E. Adams, N. Catanzaro, B. Yount, T. J. Baric, M. Mallory, H. Conrad, S. R. May, S. Dong, T. D. Scobey, , T. P. Sheahan

This study evaluates the antiviral efficacy of GS-5245 against multiple SARS-CoV-2 variants and other coronaviruses, showing broad in vitro activity and protective effects in animal models.

bioRxiv · Jun 27, 2023 · PreprintMicrobiology

Structural basis of Cas12a R-loop propagation on pathway to DNA cleavage

I. Strohkendl, C. Moy, A.-H. Nguyen, R. Russell, D. W. Taylor

This study uses cryo-EM to capture Cas12a R-loop intermediates, revealing how the enzyme accommodates R-loop extension and coordinates nuclease activation.

bioRxiv · Mar 13, 2023 · PreprintBiochemistry