R. Russell

Optimal Control Prevents Itself from Eradicating Stochastic Disease Epidemics

This paper shows that deterministic optimal control strategies are insufficient for eradicating stochastic disease epidemics and proposes heuristics that outperform Model Predictive Control in such scenarios.

Loss of VHL-mediated pRb regulation promotes clear cell renal cell carcinoma

This study identifies pRb as a novel VHL substrate, showing that its hyperstabilization promotes ccRCC tumorigenesis through transcriptional changes.

Kinetic dissection of pre-crRNA binding and processing by CRISPR-Cas12a

This study quantifies pre-crRNA binding and processing kinetics by Cas12a, revealing key sequence determinants and binding dynamics for crRNA maturation.

Structural basis of Cas12a R-loop propagation on pathway to DNA cleavage

This study uses cryo-EM to capture Cas12a R-loop intermediates, revealing how the enzyme accommodates R-loop extension and coordinates nuclease activation.

Species-specific roles for the MAFA and MAFB transcription factors in regulatingislet β cell identity

The paper investigates the species-specific roles of MAFA and MAFB in maintaining β cell identity, showing MafA in mice and MAFB in humans repress non-β cell hormones like GAST.

Pro-IL-18 secreted by keratinocytes detects the group A streptococcal protease SpeB

The paper shows keratinocytes secrete inert pro-IL-18 which is activated by GAS protease SpeB, triggering an inflammatory response against GAS.

Structural basis for template switching by a group II intron-encoded non-LTR-retroelement reverse transcriptase

This study determines the structure of a group II intron RT template-switching complex, revealing mechanisms of template switching and non-templated addition, and their implications for RNA-seq and retroelement function.

Group A Streptococcus Infection of the Nasopharynx Requires Proinflammatory Signaling Through the Interleukin-1 Receptor

This study shows that IL-1β-mediated inflammation promotes GAS infection of the nasopharynx, contrasting its protective role in skin infections.

Inhibition of CRISPR-Cas12a DNA Targeting by Nucleosomes and Chromatin

This study shows that nucleosomes inhibit CRISPR-Cas12a binding and cleavage, with DNA unwrapping enhancing accessibility and cleavage rates.