Breast tumors escape endocrine therapy by ER-independent mechanisms triggered by the coordinated activities of HER2/HER3 and deacetylated FOXA1
S. Gilfillan, S. Wang, M. R. Katika, J. H. Norum, H. Bergholtz, E. Fiorito, S. Nordhagen, Y. Sharma, S. Singh, V. S. Somisety, A.-M. Fosdahl, S. Nord, O. Engebraaten, O. C. Lingjaerde, A.-L. Borresen-Dale, , A. Hurtado-Rodriguez
This study shows that HER2/HER3 signaling and FOXA1 deacetylation drive ER-independent growth in hormone-resistant breast tumors by altering FOXA1 chromatin binding and function.
bioRxiv · Sep 22, 2020 · PreprintCancer Biology