Author

A.-P. Gadeau

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 3 Cell Biology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:mouse· 4 Research Focus:cell signaling & trafficking· 2 Research Focus:host-pathogen & immune response· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

C. Chapouly· 5 shared L. Cornuault· 5 shared M.-A. Renault· 5 shared P.-L. Hollier· 3 shared S. Guimbal· 3 shared T. Couffinhal· 3 shared N. Foussard· 2 shared P. Alzieu· 2 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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5 shared papersPhysiology

C. Chapouly

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Increased endothelium activation and leakage do not promote diastolic dysfunction in mice fed with a high fat diet and treated with L-NAME

L. Cornuault, P. Mora, P. Rouault, N. Foussard, C. Chapouly, P. Alzieu, A.-P. Gadeau, T. Couffinhal, M.-A. Renault

This study shows that endothelial activation and leakage do not contribute to diastolic dysfunction in HFD+L-NAME treated mice.

bioRxiv · Feb 8, 2023 · PreprintPathology

Cardiac pericytes are necessary for coronary vasculature integrity and cardiomyocyte differentiation

L. Cornuault, F.-X. Herion, P. Rouault, N. Foussard, P. Alzieu, C. Chapouly, A.-P. Gadeau, T. Couffinhal, M.-A. Renault

This study shows that cardiac pericyte depletion in adult mice causes coronary endothelial leakage, cardiomyocyte dedifferentiation, and systolic/diastolic dysfunction.

bioRxiv · Aug 29, 2022 · PreprintPhysiology

Mast cells participate in the development of diastolic dysfunction in diabetic obese mice

S. Guimbal, L. Cornuault, P.-L. Hollier, C. Chapouly, M.-L. Bats, A.-P. Gadeau, T. Couffinhal, M.-A. Renault

The paper investigates the role of mast cells in diastolic dysfunction in diabetic obese mice, finding that mast cell degranulation inhibition reduces end diastolic pressure and vascular leakage.

bioRxiv · Jun 16, 2020 · PreprintPhysiology

Desert Hedgehog-driven endothelium integrity is enhanced by Gas1 but negatively regulated by Cdon

C. Chapouly, P.-L. Hollier, S. Guimbal, L. Cornuault, A.-P. Gadeau, M.-A. Renault

This study investigates the roles of Gas1 and Cdon as regulators of Dhh signaling in endothelial cells, showing Gas1 enhances and Cdon inhibits Dhh effects, with implications for endothelium integrity in inflammation.

bioRxiv · Apr 20, 2020Cell Biology

Endothelial cell response to Hedgehog ligands depends on their processing

P.-L. Hollier, C. Chapouly, A. Diop, S. Guimbal, L. Cornuault, A.-P. Gadeau, M.-A. Renault

The paper shows that N-Shh and Dhh have opposing effects on endothelial cells, with N-Shh acting as a competitive antagonist to Dhh.

bioRxiv · Mar 3, 2020 · PreprintPhysiology