Targeted αGalCer/CD1d Therapy Engages Invariant Natural Killer T Cells to Facilitate Cardiac Healing in Chronic Doxorubicin-Induced Cardiomyopathy
Sarojini Singh, Roopa Hebbandi Nanjundappa, Harish Babu Kolla, Deepak S. Chauhan, Aahana Palyada, Prasanna Krishnamurthy, Channakeshava Sokke Umeshappa
This study investigates the role of iNKT cells in cardiac healing using GalCer/CD1d therapy in a Doxorubicin-induced cardiomyopathy model, finding increased IFN-γ and IL-10 without worsening cardiac damage.
bioRxiv · Sep 18, 2025 · PreprintImmunology