A human papillomavirus 16 E2-TopBP1 dependent SIRT1-p300 acetylation switch regulates mitotic viral and human protein levels
Apurva Tadimari Prabhakar, Claire D. James, Aya H. Youssef, Reafa A. Hossain, Ronald D. Hill, Molly L. Bristol, Xu Wang, Aanchal Dubey, Iain M. Morgan
This paper identifies a mitotic E2-TopBP1 complex that inactivates SIRT1, promoting E2 acetylation and stability through p300, which protects against ubiquitination and proteasomal degradation.
bioRxiv · Jan 15, 2024 · PreprintMolecular Biology