Aminoglycoside antibiotics drive RNA phase separation
Julian von Hofe, Mechi Chen, Christine Choi, Ka Wing Leung, Aarav Kokane, Kfir B. Steinbuch, Deyuan Cong, Moeka Sasazawa, Yitzhak Tor, Saumya Saurabh
This study shows aminoglycoside antibiotics induce RNA phase separation through multivalent binding, revealing a potential mechanism for their bactericidal activity and toxicity.
bioRxiv · Aug 13, 2026 · PreprintBiochemistry