Saumya Saurabh

Multiparametric microenvironment sensing via distinct molecular equilibria in a single cyanine dye

This paper introduces a single cyanine dye that encodes two ratiometric reporting channels to simultaneously sense hydrogen bonding/polarity and crowding/self-association in microenvironments.

Bacterial Ribonucleoprotein bodies maintain an acidic pH environment as a mechanism of enzyme regulation

The paper shows bacterial ribonucleoprotein bodies (BR-bodies) maintain an acidic pH environment, enhancing enzyme activity and suggesting pH regulation as a mechanism for RNA processing.

Aminoglycoside antibiotics drive RNA phase separation

This study shows aminoglycoside antibiotics induce RNA phase separation through multivalent binding, revealing a potential mechanism for their bactericidal activity and toxicity.

A tunable aqueous architecture modulates functionaloutput in biomolecular condensates

This study introduces a method to map solvent polarity landscapes within biomolecular condensates and shows how internal solvent organization affects material properties and molecular behavior.

Holographic fingerprinting reveals oligomer-driven phase separation in Bovine Serum Albumin

This study uses holographic imaging to show that Bovine Serum Albumin phase separation depends on higher-order oligomers and is tunable by pH.

Multivalency controls the growth and dynamics of a biomolecular condensate

This study uses holographic microscopy to analyze how multivalent ions affect the growth and dynamics of PopZ condensates, revealing deviations from classical models and highlighting the technique's advantages.

A Mechanical Logic for Bacterial Navigation

This study shows Caulobacter crescentus uses backward swimming controlled by mechanical forces to navigate confined environments.

PEPCy: Photostable fluoromodules for live cell, super-resolution microscopy of surface proteins

The paper introduces PEPCy, photostable fluoromodules that enhance cyanine dye photostability for live-cell super-resolution microscopy of surface proteins.

Phosphatase to kinase switch of a critical enzyme contributes to timing of cell differentiation

The paper shows that the switch of PleC from phosphatase to kinase activity, regulated by PodJ interaction, controls the timing of cell differentiation in Caulobacter crescentus.

Intranasal CRMP2-Ubc9 Inhibitor Regulates NaV1.7 to Alleviate Trigeminal Neuropathic Pain

The paper develops a CRMP2-Ubc9 inhibitor that reduces NaV1.7 activity and alleviates trigeminal neuropathic pain in rats.

Deconstructing the structural conservation of distantly related bacterial nucleoid-associated proteins using functional chimeras

This study identifies structurally and functionally conserved regions in distantly related bacterial NAPs, GapR and H-NS, and shows how these elements enable distinct regulatory mechanisms.