Author

Mechi Chen

New York University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Biophysics· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Research Focus:clustering· 1 Approach:deep learning· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Organism:E. coli· 1 Approach:experimental assay· 1 Assay:imaging· 1

Frequent Co-Authors

Julian von HofeiD· 3 shared Moeka SasazawaiD· 3 shared Saumya SaurabhiD· 3 shared Aarav Kokane· 1 shared Christine Choi· 1 shared David G. GrieriD· 1 shared Deyuan Cong· 1 shared Ida Javér KristianseniD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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3 shared papersBiochemistry

Julian von HofeORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Aminoglycoside antibiotics drive RNA phase separation

Julian von Hofe, Mechi Chen, Christine Choi, Ka Wing Leung, Aarav Kokane, Kfir B. Steinbuch, Deyuan Cong, Moeka Sasazawa, Yitzhak Tor, Saumya Saurabh

This study shows aminoglycoside antibiotics induce RNA phase separation through multivalent binding, revealing a potential mechanism for their bactericidal activity and toxicity.

bioRxiv · Aug 13, 2026 · PreprintBiochemistry

A tunable aqueous architecture modulates functionaloutput in biomolecular condensates

Moeka Sasazawa, Mechi Chen, Rui Zeng, Uvarov Denis, Sujata Bais, Jillian Hoffstadt, Julian von Hofe, Norah Hoffmann, Yulia A. Volkova, Saumya Saurabh

This study introduces a method to map solvent polarity landscapes within biomolecular condensates and shows how internal solvent organization affects material properties and molecular behavior.

bioRxiv · May 15, 2026 · PreprintBiochemistry

Multivalency controls the growth and dynamics of a biomolecular condensate

Julian von Hofe, Jatin Abacousnac, Mechi Chen, Moeka Sasazawa, Ida Javér Kristiansen, Soren Westrey, David G. Grier, Saumya Saurabh

This study uses holographic microscopy to analyze how multivalent ions affect the growth and dynamics of PopZ condensates, revealing deviations from classical models and highlighting the technique's advantages.

Journal of the American Chemical Society · Jul 8, 2025Peer-reviewedBiophysics