Aarno Palotie

An expanded analysis framework for multivariate GWAS connects inflammatory biomarkers to functional variants and disease

The paper introduces a multivariate GWAS framework that identifies functional variants and disease associations by transforming multivariate results into univariate phenotypes for follow-up analysis.

Insights into the genetic epidemiology of Crohn’s and rare diseases in the Ashkenazi Jewish population

The paper analyzes exome sequencing data from Ashkenazi Jews to identify enriched alleles and their association with genetic risk for Crohn’s disease and rare diseases.

Genomic analyses for age at menarche identify 389 independent signals and indicate BMI-independent effects of puberty timing on cancer susceptibility

This study identifies 389 genetic signals for age at menarche and finds BMI-independent causal links between puberty timing and cancer risks.

Genomic prediction of coronary heart disease

This study develops a genomic risk score for coronary heart disease and shows it improves risk prediction beyond clinical scores, particularly in older adults.

Rare schizophrenia risk variants are enriched in genes shared with neurodevelopmental disorders

This study identifies rare schizophrenia risk variants enriched in genes shared with neurodevelopmental disorders through meta-analysis of exome and copy number variant data.

Whole genome view of the consequences of a population bottleneck using 2926 genome sequences from Finland and United Kingdom

The paper compares genome sequences from Finnish and British populations to identify genetic variants enriched in a population bottleneck, finding significant enrichment of rare variants in Finns.

Ultra-rare disruptive and damaging mutations influence educational attainment in the general population

This study finds that ultra-rare disruptive variants in highly constrained genes are associated with reduced educational attainment in the general population.

Genome-wide association study identifies 17 new loci influencing concentrations of circulating cytokines and growth factors

This study identifies 17 new genetic loci associated with circulating cytokine and growth factor concentrations in Finns, linking them to immune-related diseases and potential drug targets.