Identifying a novel role for the master regulator Tal1 in the Endothelial to Hematopoietic Transition
Yasmin Natalia Serina Secanechia, Isabelle Bergiers, Zbigniew Rogon, Christian Arnold, Nicolas Descostes, Stephanie Le, Natalia López-Anguita, Kerstin Ganter, Chrysi Kapsali, Lea Bouilleau, Aaron Gut, Auguste Uzuotaite, Ayshan Aliyeva, Judith B. Zaugg, Christophe Lancrin
The paper investigates the role of Tal1, Lmo2, and Lyl1 in the Endothelial to Hematopoietic Transition using a mouse embryonic-stem cell model and multi-omics approaches, finding that Tal1 expression in endothelial cells is crucial for the transition.
bioRxiv · Oct 3, 2021 · PreprintDevelopmental Biology