Christophe Lancrin

This study shows that reducing OGT activity in mice causes embryonic lethality proportional to the reduction in O-GlcNAc modification, with milder reductions causing developmental delays and retrovirus activation.

The paper identifies transcription factors and chromatin regulators critical for haemato-endothelial mesoderm formation using CRISPR-Cas9 screens in mouse embryonic stem cells.

The paper shows that parts of the TCA cycle operate in the nucleus, challenging the canonical view of metabolic compartmentalization.

The paper uses single-cell transcriptomics to compare embryonic and adult endothelial cells, identifying adult endothelial cell types with high potential for reprogramming into hematopoietic stem cells.

The paper investigates the role of Tal1, Lmo2, and Lyl1 in the Endothelial to Hematopoietic Transition using a mouse embryonic-stem cell model and multi-omics approaches, finding that Tal1 expression in endothelial cells is crucial for the transition.

The paper identifies CD44 as a marker and regulator of haematopoietic stem cell development through single-cell transcriptomics and functional experiments.

The paper compares single-cell RNA sequencing data from Yolk Sac and AGM in mouse embryos to identify differences in hematopoietic potential and cell populations.

The paper investigates the impact of iron deficiency on embryonic hematopoiesis, finding it affects hematopoietic progenitor survival and proliferation but not the endothelial to hematopoietic transition.

The paper identifies a new pathway for red blood cell generation in the mouse embryo by discovering hemogenic endothelial cells that can produce erythrocytes independently of Runx1.