Multiplexing Mutation Rate Assessment: Determining Pathogenicity of Msh2 Variants in S. cerevisiae
Anja R. Ollodart, Chiann-Ling C Yeh, Aaron W Miller, Brian H. Shirts, Adam S Gordon, Maitreya J. Dunham
The paper introduces a high-throughput method to assess mutation rates in yeast strains with Msh2 mutations, identifying pathogenic variants by linking mutations to DNA repair gene alleles.
Genetics · Apr 13, 2021Peer-reviewedGenetics