Chiann-Ling C Yeh

Pacybara improves the accuracy of long-read sequencing for barcoded mutagenized libraries by addressing sequencing errors and non-unique barcodes.

PacRAT improves barcode-variant mapping from PacBio long reads by enhancing alignment and consensus calling, increasing usable reads in both simulated and real libraries.

The paper introduces a high-throughput method to assess mutation rates in yeast strains with Msh2 mutations, identifying pathogenic variants by linking mutations to DNA repair gene alleles.

The paper presents a high-throughput assay to measure the fitness of natural alleles in yeast, identifying functional and nonfunctional variants and their effects on phenotype.