A systematic survey of distal element-gene regulatory interactions with Direct-Capture Targeted Perturb-seq
Judhajeet Ray, Evelyn Jagoda, Maya U. Sheth, James Galante, Dulguun Amgalan, Eugenio Mattei, Andreas R. Gschwind, Chad J. Munger, Jacob Huang, Glen Munson, Madeleine Murphy, Timothy Barry, Vasundhara Singh, Aarthee Baskaran, Helen Y. Kang, , J Engreitz
This study identifies most distal element-gene interactions have small effect sizes (<10%) using DC-TAP-seq, revealing limitations in prior CRISPR screens and suggesting new model requirements.
bioRxiv · Sep 16, 2025 · PreprintGenomics