Author

Madeleine Murphy

Broad InstituteORCID 0000-0002-9052-702XUnclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Madeleine Murphy1 paper · The Heart Research Institute

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:benchmarking· 1 Assay:CRISPR screen· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1

Frequent Co-Authors

Aarthee Baskaran· 1 shared Andreas R. GschwindiD· 1 shared Chad J. MungeriD· 1 shared Charles B. EpsteiniD· 1 shared Dulguun AmgalaniD· 1 shared Elizabeth GaskelliD· 1 shared Eugene KatsevichiD· 1 shared Eugenio MatteiiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperGenomics

Aarthee Baskaran

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1 paper

Recent·Most cited

A systematic survey of distal element-gene regulatory interactions with Direct-Capture Targeted Perturb-seq

Judhajeet Ray, Evelyn Jagoda, Maya U. Sheth, James Galante, Dulguun Amgalan, Eugenio Mattei, Andreas R. Gschwind, Chad J. Munger, Jacob Huang, Glen Munson, Madeleine Murphy, Timothy Barry, Vasundhara Singh, Aarthee Baskaran, Helen Y. Kang, , J Engreitz

This study identifies most distal element-gene interactions have small effect sizes (<10%) using DC-TAP-seq, revealing limitations in prior CRISPR screens and suggesting new model requirements.

bioRxiv · Sep 16, 2025 · PreprintGenomics