Computational Stabilization of the Human VH Germline Repertoire to Enable Conditional Multi-Specific Therapeutic Development
David F. Thieker, Jayd Hanna, Pricilla White, Glenn C. Capodagli, Christen Buetz-Duncan, Christina D Carnevale, Arlene Sereno, Falene Chai, Abby Lin, Craig R. Pigott, Rajesh Sharma, Natasha Del Cid, Nathan I. Nicely, Brian A. Kuhlman, Stephen J. Demarest
The paper develops a computational platform to stabilize human VH domains for creating multispecific biologics with conditional activity.
bioRxiv · Oct 31, 2025 · PreprintBioengineering