Nathan I. Nicely

This paper introduces HBDesigner, a deep learning tool for designing hydrogen-bond networks in proteins, showing improved performance over existing methods.

This paper determines the crystal structures of 19b Fab in complex with HIV-1 V3 loop peptides, revealing the epitope and binding mode of the antibody.

The paper investigates how CCDC32 interacts with AP-2 to regulate its assembly, revealing that CCDC32 inhibits assembly and requires membrane binding for complex formation.

This paper designs orthogonal TCR β interfaces to prevent mispairing in dual-TCR therapeutics, achieving high pairing fidelity and demonstrating enhanced potency in targeting cancer antigens.

The paper develops a computational platform to stabilize human VH domains for creating multispecific biologics with conditional activity.

The paper reports the X-ray crystal structure of the N-terminal domain of Staphylococcus aureus GpsB, confirming its unique conformation and supporting its role in cell division machinery organization.