Phosphoproteomic dysregulation drives tumor proliferation in Cushing's disease
David T. Asuzu, Dhruval Bhatt, Dustin Mullaney, Debjani Mandal, Diana Nwokoye, Sheelu Varghese, Daniela Tortoza Lopez, Nikhil Ramavenkat, Kory Johnson, Abdel Elkahloun, Zied Abdullaev, Kenneth Aldape, Dragan Maric, Clarisse Quignon, N MALIK, , Prashant Chittiboina
This study identifies phosphoproteomic dysregulation as a driver of tumor proliferation in Cushing's disease and demonstrates reversibility using an FDA-approved PP2A agonist.
bioRxiv · Sep 28, 2025 · PreprintCancer Biology