CRISPRi-Linked Multi-Module Negative Feedback Loops to Address Winner-Take-All Resource Competition
Sadikshya Rijal, Kylie Standage-Beier, Rong Zhang, Austin Stone, Abdelrahman Youssef, Xiao Wang, Xiao‐Jun Tian
This study introduces a CRISPRi-based controller to mitigate Winner-Take-All behavior in synthetic gene circuits by promoting balanced module activation through negative feedback.
ACS Synthetic Biology · Sep 10, 2025Peer-reviewedSynthetic Biology