Xiao Wang

Bispecific Coiled-Coil Reporters Enable Rapid, Multiplexed Detection of Mycoplasma via Toehold Switch Sensors

This paper introduces BINOCULAR, a system for rapid, multiplexed detection of Mycoplasma using toehold switch sensors, achieving sub-5-minute readout times and 1-copy/µL sensitivity.

CRISPRi-Linked Multi-Module Negative Feedback Loops to Address Winner-Take-All Resource Competition

This study introduces a CRISPRi-based controller to mitigate Winner-Take-All behavior in synthetic gene circuits by promoting balanced module activation through negative feedback.

Winner-Takes-All Resource Competition Redirects Cascading Cell Fate Transitions

The paper demonstrates a 'winner-takes-all' resource competition in synthetic gene circuits, showing how it redirects cell fate transitions and proposes a division of labor strategy to mitigate its effects.

Topology-Dependent Interference of Circuit Function by Growth Feedback

This study shows growth feedback affects memory gene circuits differently based on network topology, with self-activation circuits losing memory faster than toggle switches.

A Synthetic Biology Approach to Sequential Stripe Patterning and Somitogenesis

This paper designs a synthetic gene circuit to study reaction-diffusion patterning in bacteria, showing how gene network topology influences stripe formation.

High Accuracy Base Calls in Nanopore Sequencing

This paper introduces an unsupervised learning method to correct errors in nanopore sequencing data, achieving performance comparable to existing techniques while preserving repeat detection and long sequence analysis.