Oncogene-Mechanics Axis: KRAS G12C Confers Agility Enabling Malignant Mechano-responses to Peristalsis in Colorectal Cancer
Astha Lamichhane, Vsevolod D. Cheburkanov, Mykyta Kizilov, Abhinav Shenoy, Audrey G Head, Vladislav Yakovlev, Shreya Artha Raghavan
This study shows that KRAS G12C mutations in colorectal cancer cells enhance mechanical agility, enabling them to respond to peristalsis by enriching LGR5+ cancer stem cells, which promotes malignant progression.
Scientific Reports · Sep 1, 2026Peer-reviewedBioengineering