Shreya A. Raghavan

This study identifies molecular differences in HR+ breast cancer between Black and White women, linking structural factors like poverty to tumor biology and immune signatures.

The paper develops a computational model to simulate inflammation-driven colon hypertrophy and motility changes in Gulf War Illness using PB-exposed mouse data.

This study shows that KRAS G12C mutations in colorectal cancer cells enhance mechanical agility, enabling them to respond to peristalsis by enriching LGR5+ cancer stem cells, which promotes malignant progression.

This paper develops IL-4-specific affibodies to control cytokine delivery and bioactivity, showing reduced IL-4 release and partial signaling inhibition in macrophages.

This paper develops NIR-II nanofluorophores for ovarian cancer imaging, showing improved brightness, stability, and targeting across multiple tumor models.

This paper introduces EMMIs, engineered myometrial microtissues, to directly measure oxytocin-induced contractility and show that prolonged oxytocin exposure reduces contractile force.

This study shows that breast milk extracellular vesicles from mothers with asthma differentially modulate cytokine release by airway smooth muscle cells depending on the donor and recipient cell type.

This study introduces an immune-competent colon assembloid model to investigate how neuroinflammation affects colonic motility, finding impaired neuronal regeneration and smooth muscle remodeling as key mechanisms.

This study shows that endothelial Piezo1 regulates vascular smooth muscle cell differentiation in zebrafish and mice by modulating klf2a levels and flow force sensing.

This study shows that oncogenic KRAS mutations in colorectal cancer cells lead to a unique mechanotransduction response to peristalsis, increasing cancer stem cell enrichment and tumorigenicity.

This study identifies how specific cell cycle checkpoint kinase dysregulations influence cancer subtype, metastasis, and treatment response in breast cancer.