Inhibition of methylthioadenosine phosphorylase provides protection from experimental acute kidney injury
Afaf Saliba, Yidong Chen, Jonathan W. Nelson, Abhinav Vetcha, Wei Wei Wang, Kang Li, Nagarjunachary Ragi, Soumya Maity, Hamid Rabb, William Brian Reeves, Kumar Sharma
This study shows that inhibiting MTAP reduces kidney injury markers and improves renal histology in AKI mouse models and links MTAP expression to kidney injury in human single-cell RNA sequencing data.
bioRxiv · Feb 19, 2025 · PreprintPathology