Kumar Sharma

Dapagliflozin mitigates hypoxia-induced metabolic stress, kidney tubular cell death and fibrosis

This study shows dapagliflozin reduces hypoxia-induced metabolic stress, cell death, and fibrosis in kidney organoids derived from human pluripotent stem cells.

Quinolinic acid metabolism may mitigate AKI to CKD transition

This study identifies quinolinic acid as a mediator of kidney injury and fibrosis, suggesting it as a potential therapeutic target for preventing AKI-to-CKD progression.

Cellular and Spatial Drivers of Unresolved Injury and Functional Decline in the Human Kidney

The paper presents a multi-modal atlas of human kidney disease, identifying cellular and spatial mechanisms of injury resolution or failure and linking them to clinical outcomes.

β-Hydroxybutyrate enhances brain metabolism in normoglycemia and hyperglycemia, providing cerebroprotection in a mouse stroke model.

This study shows that β-hydroxybutyrate reduces brain metabolic stress and infarct size in a mouse stroke model under hyperglycemic conditions.

Inhibition of methylthioadenosine phosphorylase provides protection from experimental acute kidney injury

This study shows that inhibiting MTAP reduces kidney injury markers and improves renal histology in AKI mouse models and links MTAP expression to kidney injury in human single-cell RNA sequencing data.

Quinolinic acid links kidney injury to brain toxicity

This study identifies quinolinic acid as a key metabolite linking kidney injury to brain toxicity through the kynurenine pathway in mice and humans.

Exploration and analysis of R-loop mapping data with RLBase

The paper reprocesses R-loop mapping data, develops new quality methods, and introduces RLBase, a web server for exploring and analyzing R-loop datasets.

RLSuite: An integrative R-loop bioinformatics framework

RLSuite provides a framework for analyzing R-loop data, including preprocessing, quality control, and comparison to public datasets.

Quality-controlled R-loop meta-analysis reveals the characteristics of R-Loop consensus regions

The paper reprocesses R-loop mapping datasets to assess data quality and identifies consensus R-loop regions, revealing methodological differences and biological subtypes.

A reference tissue atlas for the human kidney

The paper constructs a reference tissue atlas of the human kidney using multi-omics data to identify cell types, pathways, and genes across nephron segments and interstitium.

METASPACE: A community-populated knowledge base of spatial metabolomes in health and disease

An open-source cloud engine annotates imaging mass spectrometry data at controlled false discovery rate; publicly shared results reached over 3200 datasets and 6 million metabolite images by January 2019.