Afaf Saliba

This study identifies quinolinic acid as a mediator of kidney injury and fibrosis, suggesting it as a potential therapeutic target for preventing AKI-to-CKD progression.

This study shows that β-hydroxybutyrate reduces brain metabolic stress and infarct size in a mouse stroke model under hyperglycemic conditions.

This study shows that inhibiting MTAP reduces kidney injury markers and improves renal histology in AKI mouse models and links MTAP expression to kidney injury in human single-cell RNA sequencing data.

This study identifies quinolinic acid as a key metabolite linking kidney injury to brain toxicity through the kynurenine pathway in mice and humans.

The paper shows that partial loss of CFIm25, a protein regulated by NUDT21, causes learning deficits and molecular changes in neurons.

The paper functionally characterizes germline TMEM127 variants, identifying pathogenic mutations and revealing a fourth transmembrane domain and an endocytic motif.