Lipotoxicity Induces Beta Cell Small Extracellular Vesicle-mediated Beta Cell Dysfunction
Abhishek Roy, Alexandra Hoff, Tracy K. Her, Gallage H. D. Nipun Ariyaratne, Kamalnath Sankaran Rajagopalan, Matthew Brown, Alondra Soto-González, Aleksey V. Matveyenko, Naureen Javeed
This study shows lipotoxicity increases beta-cell sEV release, which alter proteomic/lipidomic profiles and induce beta-cell dysfunction via the TGFβ/Smad3 pathway.
bioRxiv · Jul 19, 2024 · PreprintMolecular Biology