Author

Matthew Brown

Broad InstituteORCID 0000-0001-7429-2657Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Matthew Brown3 papers · Auburn University

Biology Disciplines

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Cell Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1 Assay:metabolomics· 1

Frequent Co-Authors

Abhishek Roy· 1 shared Aleksey V. MatveyenkoiD· 1 shared Alexandra Hoff· 1 shared Alondra Soto-GonzáleziD· 1 shared Anna GrekaiD· 1 shared Choah KimiD· 1 shared Dylan Boone· 1 shared Gallage H. D. Nipun AriyaratneiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperMolecular Biology

Abhishek Roy

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2 papers

Recent·Most cited

Cell BiologyScience AdvancesPeer-reviewedJul 2, 2025

FAF2 is a bifunctional regulator of peroxisomal homeostasis and saturated lipid responses

Choah Kim, Katlyn R. Gabriel, Dylan Boone…·Anna Greka

This study identifies FAF2 as a bifunctional regulator of peroxisomal homeostasis and saturated lipid responses through a CRISPR knockout screen in human cells.

9 citations

humangenetic perturbation / CRISPR

𝕏 PostBluesky

Molecular BiologybioRxivPreprintJul 19, 2024

Lipotoxicity Induces Beta Cell Small Extracellular Vesicle-mediated Beta Cell Dysfunction

Abhishek Roy, Alexandra Hoff, Tracy K. Her…·Naureen Javeed

This study shows lipotoxicity increases beta-cell sEV release, which alter proteomic/lipidomic profiles and induce beta-cell dysfunction via the TGFβ/Smad3 pathway.

DOI 10.1101/2024.07.19.604353

𝕏 PostBluesky