Molecular BiologybioRxivPreprint
Lipotoxicity Induces Beta Cell Small Extracellular Vesicle-mediated Beta Cell Dysfunction
Abhishek Roy, Alexandra Hoff, Tracy K. Her…·Naureen Javeed
This study shows lipotoxicity increases beta-cell sEV release, which alter proteomic/lipidomic profiles and induce beta-cell dysfunction via the TGFβ/Smad3 pathway.