Absence of a prolonged macrophage and B cell response inhibits heart regeneration in the Mexican cavefish
Esra Sengul, Helen G. Potts, William T. Stockdale, Rene Carter, Laura Bevan, Maria Nozdrina, Rita Alonaizan, Zhilian Hu, Abigail Goodship, Jun Ying, Konstantinos Lekkos, Lucy O’Byrne, Madeleine E. Lemieux, Rebecca J. Richardson, Mathilda T.M. Mommersteeg
The paper identifies prolonged innate and adaptive immune responses as critical for heart regeneration in surface fish, showing that inhibiting these responses impairs regeneration.
bioRxiv · Apr 24, 2025 · PreprintDevelopmental Biology