Stimulating neurogenesis of distinct retinal lineages in human retinal pigmented epithelium (RPE) with proneural transcription factors
Lew Kaplan, Abigail L. Green, Jaz Pang, Marina Pavlou, Juliette Wohlschlegel, Thomas A. Reh
The paper identifies NEUROD1 as a factor that, when combined with ASCL1, bFGF, and an Activin A inhibitor, can reprogram human RPE into photoreceptor-like cells.
bioRxiv · Aug 20, 2026 · PreprintDevelopmental Biology