Lew Kaplan

The paper uses long-read single-cell transcriptomics to study isoform preferences in developing human retina and identifies alternative splicing events that may contribute to cell differentiation.

The paper identifies NEUROD1 as a factor that, when combined with ASCL1, bFGF, and an Activin A inhibitor, can reprogram human RPE into photoreceptor-like cells.

This study presents two whole genome sequencing pipelines to identify and genotype transgene insertion sites in transgenic mice, enabling accurate zygosity determination and breeding strategies.

This study shows that ASCL1 can reprogram adult and infant macaque Müller glia into retinal ganglion cell-like neurons using a modified vector cassette.

This study shows that AAV-mediated delivery of proneural factors to adult Müller glia stimulates neurogenesis in vivo, producing neurons similar to those in the retina.

The paper identifies the glucocorticoid receptor as a master regulator of Muller cell gliosis in diabetic retinopathy and shows that increasing GR expression can improve retinal function.

The paper identifies VAMP5 as a SNARE component in extracellular vesicles released by retinal Muller glia and shows differences in their secretomes compared to neurons.

The paper investigates harmonin expression and localization in human retinas to understand USH1C pathophysiology and potential gene therapy approaches.