Granulin loss and TMEM106B risk converge on lysosomal C-terminal fragment pathology in frontotemporal dementia
Yi Zeng, Jian Xiong, Anastasiia Lovchykova, Thao Phuong Nguyen, Abigail Song, Semma W. Gitler, Monther Abu-Remaileh, Aaron D. Gitler
The paper shows granulin deficiency leads to lysosomal buildup of a TMEM106B C-terminal fragment, explaining how TMEM106B alleles influence FTD risk.
bioRxiv · Mar 27, 2026 · PreprintGenetics