Anastasiia Lovchykova

The paper shows granulin deficiency leads to lysosomal buildup of a TMEM106B C-terminal fragment, explaining how TMEM106B alleles influence FTD risk.

The paper shows that TDP-43 loss causes cryptic splicing events that are masked by nonsense-mediated decay, and inhibiting this decay reveals hundreds of novel splicing events.

This study shows that TDP-43 nuclear loss in FTD/ALS causes widespread alternative polyadenylation changes affecting disease-relevant genes.