Monther Abu-Remaileh

This study identifies HexBMP(22:6_22:6) as a novel biomarker for mutant GBA1 using lysosomal profiling in mice and human samples.

This study identifies CLN6 as a glycerophosphoglycerol epimerase that converts R,S-GPG to S,S-GPG, establishing the S,S-BMP stereochemistry critical for lysosomal function.

This study develops LC/MS methods for accurate BMP profiling, using CLN5 knockout cells to distinguish BMP from PG and introduce BMPII and BMPES metrics.

The paper identifies a mitochondrial degradation pathway for metallothionein that releases zinc during zinc limitation, maintaining metabolic homeostasis.

This study identifies biallelic LRRK2 loss-of-function variants as a cause of interstitial lung disease, showing reduced LRRK2 protein and impaired lung function in affected individuals.

The paper introduces GlycoShuttles, mucin-binding protein shuttles that deliver therapeutics across the blood-brain barrier into brain cells, showing efficacy in dementia models.

The paper shows granulin deficiency leads to lysosomal buildup of a TMEM106B C-terminal fragment, explaining how TMEM106B alleles influence FTD risk.

This study identifies BMP and LPG as biomarkers for CLN5 Batten disease using lipidomics, showing their depletion and elevation in disease models and patient samples.

The paper creates a cell-type-specific lysosome protein atlas in the brain, identifies SLC45A1 as a neuron-specific lysosomal protein, and shows its role in lysosomal function and neurodegeneration.

The paper develops human tri-lineage brain microtissues composed of neurons, astrocytes, and microglia, showing they recapitulate cell-cell interactions and pathological processes.

This study identifies PLA2G15 as a lysosomal BMP hydrolase and shows its targeting improves lysosomal disease symptoms in NPC1 models.

The paper develops a tagless LysoIP method to isolate lysosomes from clinical samples and human cell lines, revealing glycerophosphodiesters as potential biomarkers for lysosomal storage disorders.

The paper identifies a microglia population that takes up circulatory proteins, enhancing phagocytosis and innate immunity through ApoA-I uptake.

The paper links APOE4/4 genotype to lipid droplet accumulation in Alzheimer's microglia, showing its role in neurotoxicity through triglyceride synthesis and Tau phosphorylation.

The paper introduces MITO-Tag Mice to isolate mitochondria from specific cell types in vivo and identifies mitochondrial metabolite changes during fasting and refeeding in hepatocytes.