Tsc1 Deletion in Purkinje Neurons Disrupts the Axon Initial Segment, Impairing Excitability and Cerebellar Function
Samuel P. Brown, Achintya K. Jena, Joanna J. Osko, Joseph L. Ransdell
This study shows Tsc1 deletion in Purkinje neurons disrupts axon initial segment organization, reducing sodium currents and impairing neuronal firing and cerebellar function.
Neurobiology of Disease · Feb 25, 2025Peer-reviewedNeuroscience