Samuel P. Brown

This study shows that a mutation in FGF14 causes haploinsufficiency and impairs Purkinje neuron firing, leading to motor and cognitive deficits in mice.

This study shows Tsc1 deletion in Purkinje neurons disrupts axon initial segment organization, reducing sodium currents and impairing neuronal firing and cerebellar function.

This study investigates sex-specific behavioral impairments in Tsc1 mutant mice, finding similar motor deficits but more severe social impairments in males.

The paper investigates the role of resurgent (INaR) and persistent (INaP) sodium currents in regulating repetitive firing in Purkinje neurons, finding that INaP, not INaR, is critical for firing rate control.