Adèle L’Hostis

The paper introduces four empirical methods to validate time-to-event models in EGFR+ lung adenocarcinoma, considering uncertainty and variability, and shows their context-dependent effectiveness.

The paper describes a calibration strategy for multiscale mechanistic models using heterogeneous data, demonstrating its application to a lung adenocarcinoma model.

The paper uses single molecule imaging to study HIV-1 promoter pausing and finds that stochastic pausing leads to transcriptional bursting in latent cells.