Stochastic pausing at latent HIV-1 promoters generates transcriptional bursting
Katjana Tantale, Encar García-Oliver, Marie-Cécile Robert, Adèle L’Hostis, Yueyuxiao Yang, Nikolay Tsanov, Rachel Topno, Thierry Gostan, Alja Kozulic-Pirher, Meenakshi Basu Shrivastava, Kamalika Mukherjee, Věra Slaninová, Jean‐Christophe Andrau, Florian Mueller, Eugenia I. Basyuk, , Édouard Bertrand
The paper uses single molecule imaging to study HIV-1 promoter pausing and finds that stochastic pausing leads to transcriptional bursting in latent cells.
Nature Communications · Jul 23, 2021Peer-reviewedSystems Biology