Screening of FDA-approved small molecules to discover inhibitors of the Pseudomonas aeruginosa quorum-sensing enzyme, PqsE
Hannah A. Jones, Mary J. Baxter, Nicolas Zimmermann, Ada Li, Katelynn A. Perrault, Isabelle R. Taylor
This study screens FDA-approved drugs to find PqsE inhibitors, identifying three molecules, including Vorinostat, which inhibits PqsE activity and may disrupt P. aeruginosa pathogenesis.
Biochemistry · Jan 14, 2026Peer-reviewedBiochemistry