Isabelle R. Taylor

This study designs and evaluates new inhibitors of PqsE, an enzyme in P. aeruginosa, to disrupt its interaction with RhlR and reduce virulence.

This study screens FDA-approved drugs to find PqsE inhibitors, identifying three molecules, including Vorinostat, which inhibits PqsE activity and may disrupt P. aeruginosa pathogenesis.

This study shows that PqsE modulates RhlR activity in Pseudomonas aeruginosa through promoter-specific interactions, affecting gene expression and pathogenic behaviors.