Failure of DNA repair leads to the tumorigenic transformation of a regenerating blastema in Drosophila imaginal discs
Tanroop Kaur, Ada Repiso, Ying Liu, Paula Doria-Borrell, Joan Urgell, Luis Rodriguez-Escudero, Katerina Karkali, Yanhui Hu, Norbert Perrimon, Enrique Martı́n-Blanco
This paper shows that repeated tissue regeneration in Drosophila imaginal discs can lead to tumorigenesis without oncogene activation or tumor suppressor loss, highlighting a link between chronic injury and cancer.
bioRxiv · Oct 24, 2025 · PreprintDevelopmental Biology