Norbert Perrimon

This study maps spatial metabolic activity in adult fruit flies using isotope tracing and mass-spectrometry imaging, revealing compartmentalized nutrient use across tissues.

The paper shows that ABC transporters in Drosophila intestinal stem/progenitor cells reduce compound accumulation and enhance survival during cytotoxic stress.

FlyAnatoView projects Drosophila scRNA-seq data onto anatomical diagrams to restore spatial context and enable exploration of gene expression patterns across tissues.

The paper shows that de novo lipogenesis regulates lysosomal enzyme export from the ER by promoting Arf1 myristoylation and retrograde vesicle trafficking.

The paper identifies genes involved in octanoic acid resistance by combining experimental evolution and CRISPR screens in Drosophila species.

A tiered catalogue of 5,280 Drosophila genes encoding putative secreted proteins (1,802 high-confidence) with a web portal; these genes are less conserved, more tissue-restricted and disproportionately down-regulated with age.

FlyPredictome scores 1.5 million AlphaFold-Multimer predictions of Drosophila protein pairs with a contact-aware integrated Local Interaction Score (iLIS), yielding residue-level interfaces enriched for phenotype-associated missense alleles.

The paper uses a pro-apoptotic CRISPR screening strategy in mosquito cells to identify Lachesin as a critical CHIKV entry factor.

This study uses in-situ glial cell-surface proteomics in Drosophila to identify DIP-β as a pro-longevity factor regulated by glial cells.

This study identifies Lachesin as a mosquito receptor for multiple arthritogenic alphaviruses using CRISPR screening in Aedes albopictus cells.

DIOPT updates its ortholog prediction tool to include more species and algorithms, enhancing its utility for cross-species genomic analysis.

This study presents a single-nucleus transcriptomic atlas of Drosophila treated with rapamycin, identifying a sex-biased convergent aging trajectory and its modulation by rapamycin.

The paper shows that lipid metabolism in Drosophila hepatocyte-like cells supports intestinal tumor growth through the TORC1-Hnf4 pathway, with potential therapeutic implications for cancer-associated metabolic dysfunction.

This study shows that Drosophila NECAP inhibits light-induced Rhodopsin-1 internalization, preventing retinal degeneration.

LIVIA is a browser-based tool that assesses and visualizes predicted protein interactions by computing confidence metrics and providing 3D visualization options.

This study maps central carbon metabolism in Hippo-Yki-driven Drosophila gut tumors, revealing conserved metabolic principles shared with mammalian cancer metabolism.

The paper develops a genome-wide CRISPR-Cas9 knockout screening platform for Ixodes scapularis ticks and identifies genes associated with cellular fitness and drug resistance.

The paper identifies endogenous nucleophilic metabolites that neutralize reactive acyl species, reducing protein acylation and extending lifespan in model organisms.

The paper maps the Drosophila secretome to identify tissue-specific origins and inter-organ trafficking of 535 blood plasma proteins.

This study shows that renal CoA production from VB5 supports gut stem cell proliferation and tumor growth in Drosophila, with implications for human cancer.

This paper develops PD-iPCR to detect low-abundance secreted proteins in Drosophila by using nanobodies and tagged proteins, enabling sensitive quantification of hormones like ImpL2.

The paper identifies tumor-induced factors that reduce brain NPF signaling, leading to low protein appetite and early organ wasting in a fly model of cancer cachexia.

This study uses a Drosophila model to show that CFTR loss reduces cholinergic signaling, which contributes to gut pathologies, and that restoring cholinergic signaling can rescue these phenotypes.

The paper shows that Drosophila proventriculus cells compensate for age-related cell loss through endocycling rather than stem cell proliferation.

The paper identifies Zrf1 as an epigenetic factor regulating intestinal stem cell proliferation and genome stability in Drosophila midgut regeneration.

This paper shows that repeated tissue regeneration in Drosophila imaginal discs can lead to tumorigenesis without oncogene activation or tumor suppressor loss, highlighting a link between chronic injury and cancer.

The paper constructs a structure-guided kinase-transcription factor interactome atlas using AlphaFold-Multimer predictions, revealing docking motifs and allosteric hotspots that regulate kinase activity and lipid metabolism.

The paper identifies Attractin as the receptor for Nigritoxin, a Vibrio toxin, and shows that related toxins use this receptor but have distinct effector domains.

The paper identifies a cytokine-lipid axis that links systemic inflammation to hepatic autophagy dysfunction in cancer across species.