Yanhui Hu

This study maps spatial metabolic activity in adult fruit flies using isotope tracing and mass-spectrometry imaging, revealing compartmentalized nutrient use across tissues.

FlyAnatoView projects Drosophila scRNA-seq data onto anatomical diagrams to restore spatial context and enable exploration of gene expression patterns across tissues.

A tiered catalogue of 5,280 Drosophila genes encoding putative secreted proteins (1,802 high-confidence) with a web portal; these genes are less conserved, more tissue-restricted and disproportionately down-regulated with age.

FlyPredictome scores 1.5 million AlphaFold-Multimer predictions of Drosophila protein pairs with a contact-aware integrated Local Interaction Score (iLIS), yielding residue-level interfaces enriched for phenotype-associated missense alleles.

The paper uses a pro-apoptotic CRISPR screening strategy in mosquito cells to identify Lachesin as a critical CHIKV entry factor.

This study uses in-situ glial cell-surface proteomics in Drosophila to identify DIP-β as a pro-longevity factor regulated by glial cells.

This study identifies Lachesin as a mosquito receptor for multiple arthritogenic alphaviruses using CRISPR screening in Aedes albopictus cells.

DIOPT updates its ortholog prediction tool to include more species and algorithms, enhancing its utility for cross-species genomic analysis.

The paper shows that lipid metabolism in Drosophila hepatocyte-like cells supports intestinal tumor growth through the TORC1-Hnf4 pathway, with potential therapeutic implications for cancer-associated metabolic dysfunction.

This study maps central carbon metabolism in Hippo-Yki-driven Drosophila gut tumors, revealing conserved metabolic principles shared with mammalian cancer metabolism.

The paper develops a genome-wide CRISPR-Cas9 knockout screening platform for Ixodes scapularis ticks and identifies genes associated with cellular fitness and drug resistance.

The paper maps the Drosophila secretome to identify tissue-specific origins and inter-organ trafficking of 535 blood plasma proteins.

This study shows that renal CoA production from VB5 supports gut stem cell proliferation and tumor growth in Drosophila, with implications for human cancer.

This study uses a Drosophila model to show that CFTR loss reduces cholinergic signaling, which contributes to gut pathologies, and that restoring cholinergic signaling can rescue these phenotypes.

The paper shows that Drosophila proventriculus cells compensate for age-related cell loss through endocycling rather than stem cell proliferation.

The paper identifies Zrf1 as an epigenetic factor regulating intestinal stem cell proliferation and genome stability in Drosophila midgut regeneration.

This paper shows that repeated tissue regeneration in Drosophila imaginal discs can lead to tumorigenesis without oncogene activation or tumor suppressor loss, highlighting a link between chronic injury and cancer.

The paper constructs a structure-guided kinase-transcription factor interactome atlas using AlphaFold-Multimer predictions, revealing docking motifs and allosteric hotspots that regulate kinase activity and lipid metabolism.

The paper identifies Attractin as the receptor for Nigritoxin, a Vibrio toxin, and shows that related toxins use this receptor but have distinct effector domains.

The paper identifies a cytokine-lipid axis that links systemic inflammation to hepatic autophagy dysfunction in cancer across species.

The paper introduces IntAC, a CRISPR screening method for Drosophila cells that improves accuracy by suppressing early Cas9 activity, leading to a more comprehensive list of fitness genes.

This study shows that activating the UPR in muscle cells reprograms metabolism from carbohydrate to lipid metabolism through transcriptional changes.

TF2TG integrates TF-DNA binding, protein-protein interactions, and transcriptomic data to identify and rank potential target genes for Drosophila transcription factors.

DARG provides a database of Alzheimer-related genes in model organisms, enabling users to search human genes, find orthologs, and access expression and phenotype data in Drosophila.

CESA identifies potential phospho-specific antibodies from mammalian collections that could be useful for detecting phosphorylated proteins in Drosophila and other species.

This study identifies coagulation and immune factors secreted by Drosophila gut tumors that contribute to cachexia via NFκB and JNK pathways.

The paper uses a genome-wide CRISPR screen in Anopheles mosquito cells to identify essential genes and factors involved in clodronate liposome function.

This study builds tissue-specific metabolic models for Drosophila to identify metabolic dysregulation in muscle caused by a high sugar diet.

This study creates a Drosophila tauopathy model with the P251L mutation and uses single-cell RNA sequencing to identify molecular changes in neuronal and glial cells.

A Local Interaction Score (LIS), computed from AlphaFold-Multimer predicted aligned error, separates curated fly and human protein interactions from controls better than ipTM, recovering small or flexible interfaces.