Site Specific Hydration Contributes to the Thermal Stability of Proteins and Protein-Complexes
Robert L. Rider, Zhenyu Xi, Adam Hillaire, Joanna Powell, Amy Spelbring, Kacie A. Evans, Carter Lantz, Elena Scott, D.P. Barondeau, Shannon Raab, David E. Clemmer, Arthur D. Laganowsky, David H. Russell
This study investigates how site-specific hydration affects the thermal stability of proteins and protein complexes using D2O and experimental methods, revealing that stabilization depends on both hydration extent and water interaction sites.
bioRxiv · Oct 28, 2026 · PreprintBiochemistry