Adam I. Riker

Sulindac Sulfide Suppresses Oncogenic Transformation Through let-7b-Mediated Repression of K-Ras Signaling

This study shows sulindac sulfide inhibits cell transformation by upregulating let-7b, which suppresses K-Ras signaling through ERK inhibition, revealing a novel regulatory axis in cancer chemoprevention.

Sulindac modulates the response of triple negative breast cancer to anti-PD-L1 immunotherapy

This study shows that sulindac enhances anti-PD-L1 immunotherapy efficacy in TNBC by reducing exosomal PD-L1 and increasing T cell infiltration.